She is the mother of Kotoe Amano and the maternal grandmother of Misao Amano.

Battle Programmer Shirase, also known as BPS, is a free programmer with super hacking abilities who doesn't work for money. What he does work for is certainly something that only people like him would appreciate. But, his demeanor certainly doesn't suit the jobs he is hired for. With the evil King of America causing trouble via the internet, Shirase is nothing but busy as each new adventure brings even more interesting people into the picture.
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(Source: Anime News Network)
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Mitsuko Shirase