Holmes is a detective who displays little aptitude for the job. He spends his time primarily in his apartment, avoiding any exertion. Despite his lack of skill, he nevertheless is apparently famous enough to have attracted an acolyte in Hudson, his assistant. 

The great detective Holmes does not solve mysteries or use deductive reasoning. He does, however, hunt vampires. Using three-minute episodes, Vampire Holmes retells the story of the great Holmes and his assistant. What begins as an ordinary detective agency takes a turn for the occult when the Metropolitan Police of London secretly hire Holmes and Hudson to investigate vampires.