During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis, are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality. 
Based on the award winning light novels of the same name, this anime adaptation follows several events that initially seem unrelated, both in time and place, but are part of a much bigger story&mdash;one of alchemy, survival and immortality. Merging these events together are the kindhearted would-be thieves, Isaac and Miria, connecting various people, all of them with their own hidden ambitions and agendas, and creating lifelong bonds and consequences for everyone involved. 
(Source: MAL Rewrite)

Aboard the Advenna Avis in 1711, a group of alchemists summon a demon in the hopes of gaining eternal life. The demon gives them an elixir of immortality and the method of ending their existence by "devouring" one another. Soon after, one among them begins to devour his companions. Realizing the danger posed by staying together, they scatter across the globe. 
Centuries later in 1930's America, a certain federal investigator tries his best to combat the rise of organized crime during Prohibition, send a particularly infuriating terrorist to Alcatraz, and catch an outrageous thief duo. Meanwhile, the transcontinental train, the Flying Pussyfoot, begins its trail of blood across the country. 
In 2002, a small group of the original Advenna Avis alchemists are on a journey to find the rest of their fellow immortals. However, there is one companion they did not expect to meet again. 
Seemingly unrelated events, from a sleepy Italian city in the early 1700's to a modern luxury cruise ship traveling across the Pacific, reveal themselves to be far more connected than anyone could imagine... 
(Source: Wikipedia &amp; MAL Rewrite)

Gustavo Bagetta