Reika Ohtori is an employee of Hypnos. She is also the love interest of her manager, Mitsuo Yamaki, who she assists throughout the series, and to whom she also serves as an emotional counterweight to his obsessive, persistent demeanor.

Takato Matsuda, Ruki Matsuno, and Lee Jenrya are children who have, by fate, received real Digimon, unlike the imaginary ones in the card game they play. Each of the children, or "Digimon Tamers", have their different views on how Digimon should be treated. But when other Digimon begin to appear around Japan, they must put aside their differences to fend off the digital intruders; even though Yamaki, who is the head of a secret organization called Hypnos is trying to eliminate all of the Digimon himself.
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(Source: Anime News Network)

Non-anime roles:  
- Akane Morishita in "True Love Story 2" (VG) (Japanese)
- Lute in "Fire Emblem Heroes" (VG) (Japanese)

Locomon, a train digimon, has suddenly appeared in the real world. All the tamers scramble to stop the train before it reaches its final destination: the portal into the Digital world.
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(Source: Anime News Network)