Sakura is the mother of Weed (and two other puppies: Joe and Yukimura). She contracts a deadly illness soon after giving birth and dies at the very beginning of the series, resulting Weed to begin his journey.

A dog named Weed happens to hear that he is the son of Gin, The great leader of Ohu, Who lead the dogs of Ohu to victory in a fight against monsterous bear Akakabuto. Weed wants to find his father no matter of what. On a way to his father Weed meets many friends and enemies.
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(Source: Anime News Network)

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A wild dog named Weed happens to hear that he is the son of Gin, the great leader of Ohu, who lead the dogs of Ohu to victory in a fight against the monstrous bear Akakabuto. Weed wants to find his father no matter of what. On his search, Weed meets many friends and enemies.
