Fuse are a hybrid creatures of humans and dogs. As there were rumors saying that they killed humans and ate their souls, the Shogun Government offered high bounty for hunting them. 
 
Hamaji is a young female huntress living in the rural part of Mutsu while her brother Dousetsu was living in Edo. The story began as Hamaji went to Edo in order to help her brother to earn some bounty. But in Edo, she met a mysterious young men being chased by others. His name is Shino... 
 
(Source: Wikipedia) 
 
Volume 2 contains the gaiden "Kemono no Michi" (獣の道).

Hamaji, a young huntress from the mountains, stumbles into the middle of a shogun's vendetta against a group of human and dog hybrids - the Fuse. Rumors of Fuse murdering innocent people in the bustling city of Edo have sparked a bounty for their heads. Hamaji joins the hunt for this dangerous quarry along with her brother, but after accidentally befriending one of them, Hamaji is torn between two worlds: her life as a self-reliant huntress, and the young woman her new friend has helped her to uncover. 
 
(Source: Anime Limited)

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