The Matsuno sextuplets (leader Osomatsu, wannabe tough guy Karamatsu, straight man Choromatsu, cynical Ichimatsu, cheerfully stupid Jyushimatsu and lovable spoiled Todomatsu) are now in their 20s, still living together in the same house as NEETs. Their neighbors still include such eccentric characters as fish market idol Totoko, loud bucktoothed troublemaker Iyami, tiny rival Chiba, wacky inventor Dekapan, and giant mouthed glutton Dayon. 
 
Join the Matsuno siblings as they overcome mundane hurdles in their daily lives, such as finding employment, figure out who should pay the bar bill, and who should get the extra pastry!

The would-be hijinks of the mischievous Matsuno sextuplets are hijacked from episode one by colorful buck-toothed con man Iyami and Chibita, his bald munchkin sidekick. Nearly every episode is a standalone comedy cavalcade with the above cast as well as other quirky locals who show up in a number of different roles as the series shifts effortlessly between time periods and genres, but in most cases, Iyami and Chibita are front and center as partners in crime, a couple of sad sacks scraping by but carrying out scammy schemes in order to get rich quick. 
(Source: Discotek Media)

Episode 3.5 features two short segments titled "Matsu-jiru" and "Douteina Hero." 
 
Matsu-jiru - One day, the Matsuno boys are greeted by a morning different from usual... A special day for them begins. 
 
Douteina Hero - One day, Choromatsu discovers a group of college students enjoying a barbecue. But he feels inferior next to these college students who live in a different world. What's revealed is...
 
(Source: Anime News Network)

Shorts included in the Osomatsu-san BD & DVD releases.

A special episode of Osomatsu-san made in collaboration with the Japan Racing Association (JRA).

The film centers on the sextuplets at a high school class reunion. There, they see all their former classmates who have become "proper" adults with company jobs. The sextuplets sulk about this and go home and drink until they fall asleep. But when they wake up, a certain scene awaits them. 

(Source: Anime News Network)

Matsuno household has six naughty and mischievous sons (who are sextuplets), led by the eldest Osomatsu. They were grade schoolers back in the Showa period, but despite of still living in the same old household, the street view as well as the life style of modern day society have changed drastically.
 
The manga holds an original story, completely different from the one in the anime.
 
Note: Chapter count includes 1 extra.

Matsuno household has six naughty and mischievous sons (who are sextuplets), led by the eldest Osomatsu. They were grade-schoolers back in the Showa period, but despite still living in the same old household, the street view, as well as the lifestyle of modern day society, have changed drastically. 
 
(Source: ANN)

In Osomatsu-san: Hipipo-zoku to Kagayaku Kajitsu, the sextuplets embark on a grand adventure in search of a legendary fruit that is said to grant the greatest wish of whomever consumes it. 
(Source: Crunchyroll, edited) 

Note: To commemorate the 6th anniversary of Osomatsu-san anime, two new animation projects that will have a theatrical release were announced at the "Fes Matsu-san '21" event, with one in 2022, and the other the following year.

In Osomatsu-san: Tamashii no Takoyaki Party to Densetsu no Otomari-kai, the story begins with the sextuplets prepping for a takoyaki-cooking party at their home, before everything goes haywire when Totoko implies a sleepover. 

(Source: Anime News Network, edited)
 

Note: To commemorate the 6th anniversary of Osomatsu-san anime, two new animation projects that will have a theatrical release were announced at the "Fes Matsu-san '21" event, with one in 2022, and the other the following year.

Special short anime for the Osomatsu-san series exclusive to the dTV streaming service.
 
The short series will be divided into two arcs. The "Totoko x Muttsugo" (Totoko x Sextuplets) arc will feature the six brothers having conversations with Totoko, who will be depicted as "a certain princess." This story will have six "versions," one for each brother. The "Iyami x Muttsugo" (Iyami x Sextuplets) arc will feature the six brothers and their everyday life with Iyami. It will also have six "versions," one for each brother.
 
(Source: Anime News Network)

Matsuinu follows the everyday adventures of six round and cuddly pooches that lead peaceful and relaxing lives, encouraging the audience to share in their warm and fluffy feelings. 

(Source: Crunchyroll News)

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