A story set in the mid-1800's about a young doctor who has been trained in Western-style medicine and a young samurai who is trying to live up to the old traditions of his class and culture. The story is actually based upon real people - the doctor, Ryo-an, was Tezuka's great grandfather. 
During the Second Year of Ansei (1855) in Edo's Koishigawa are two young men, Manjiro Ibutani and Ryoan Tezuka. Ibutani is a low-ranking samurai who is a gifted swordsman and has a straightforward and strong sense of justice. Tezuka has a more carefree attitude. He has an eye for the ladies, but he is passionate about becoming a doctor. The two opposite characters come of age during the backdrop of the turbulent end of the Tokugawa Period (1600-1868 CE). 
(Source: AnimeNfo)

Edo, 1855, in the Hill of the Three Hundred district: Japan's isolationist foreign policy has been lifted, and the era of the Bakumatsu has begun. The samurai Ibuya Manjiro, 26 years old, has just begun his career as low-ranking retainer to the minor daimyo Lord Matsudaira. Tezuka Ryoan, 29, a disciple of Dutch medicine, has just been accepted as a student at Teki Academy in Osaka. Each has a temper to go with his talent, and in a time of brewing upheaval the two are not slow to find trouble, which brings them together in spite of their mutual dislike. Tezuka is called in one night to sew up Ibuya after an illicit duel; a few weeks later, Ibuya finds himself the only thing standing between Tezuka and a gang of swordsmen sent by the head of medicine for the Shogunate.
 
Note: Won the Shogakukan Manga Award for general manga in 1984.

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