Lilith was the prototype for Cain, Abel, and Seth and the fourth of the test tube babies created for the Mars Colonization Project by United Nations Scientists. She was in charge of the Health Care area and usually acted as the voice of reason during the conflicts between the Nightroad siblings. During the war, Lilith sided with humanity and the Vatican to save them from the Methuselah, while the three Nightroad siblings joined the Methuselah. Lilith began to convince Abel that his hatred for humans could be wrong. For this, toward the end of the war, Cain tricked her into meeting him for peace and he murdered her. Abel took her body to the Vatican where it lies encased in glass in an underground tomb in Rome. Abel remained in her tomb for 900 years to mourn her death, before rescuing a young Caterina from vampires, leading him to protect the humans as Lilith had. In the anime series, Lilith's Crusnik nanomachines are used to revive Abel from a death-like state. In the novels, Cain absorbs Crusnik O4's nanomachines.

The background is in the distant future after the destruction brought about by Armageddon. The war between the vampires and the humans continue to persist. In order to protect the humans from the vampires, the Vatican has to rely on other allies to counter the situation. The protagonist,  Abel Nightroad, is a traveling priest from the Vatican and a crusnik, a vampire that drinks the blood of vampires. He is a member of the "Ax", a special operations group led by Cardinal Catherina Sforza. He encounters a young girl called Esther, who decides to go with him to Rome and train at the Vatican. Soon after he meets her, the order of Rozencreuz, led by Abel's twin, Cain, tries to continue the war so they can rule the world. It's up to Abel and the AX to try and stop them.

There are two sets of Novels in Trinity Blood, Reborn on the Mars (R.O.M.) and Rage Against The Moons (R.A.M.). The events in Rage Against the Moons take place before those in Reborn on The Mars. The books were written by Yoshida Sunao (and after his death, continued by Kentaro Yasui) with illustrations done by THORES Shibamoto. There are also 5 manga volumes currently available; the anime is produced by GONZO and there are 24 episodes in total. Similar in feel to a Hellsing or Trigun. The background is in the distant future, a post-apocalyptic world after the destruction brought about by Armageddon. The war between humans (Terran) and vampires (Methuselah) continues, as a struggle between two factions: the Vatican and the New Human Empire. Yet amidst the bloodshed and violence, many desire a peaceful co-existence between the two species. However, standing between them and this goal is the Rosenkreuz Orden, a group of vampire extremists who manipulate the two sides and pit them against each other. To combat them, the Vatican special operations group "AX", led by Cardinal Caterina, must use everything they have - even a Crusnik (a vampire who preys on the blood of other vampires) to protect the peace effort. 
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(Source: Tokyopop)

Lilith Sahl