This film was based on a real-life 1976 accident in Italy, when deadly dioxins threatened the area surrounding a biological research laboratory where an explosion took place.

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**Non-anime roles:**
- Aile - Rockman ZX Advent (VG)
- Akari Tatsushiro - Naruto Shippuden: Ryujinki (VG)
- Akira Okuzaki - Mai-HiME: Bakuretsu! (VG)
- Aleria - Final Fantasy Crystal Chronicles: Ring of Fates (VG)
- Alex Russo - Wizards Of Waverly Place (Japanese dub)
- Allen Walker - J-Stars Victory VS (VG)
- Ashley Hammond/Yellow Ranger - Power Rangers in Space (Japanese dub)
- Ashley Hammond/Yellow Ranger - Power Rangers Lost Galaxy (Japanese dub)
- Cecilia Lynne Adlehyde - Wild Arms Alter Code: F (VG)
- Charabom - Bomberman Generation (VG)
- Constable Neyla - Sly 2: Band of Thieves (VG)
- Dalia Hakbarah - You Don't Mess with the Zohan (Japanese dub)
- Ender - .hack//Link (VG)
- Fumiko Kii - Inazuma Eleven Strikers (VG)
- Gemini Sunrise - Project X Zone (VG)
- Gemini Sunrise - Sakura Taisen 5 Saraba Itoshiki Hito Yo (VG)
- Gemini Sunrise - Sakura Wars 5 Episode 0 (VG)
- Guel in "Inazuma Eleven Strikers" (VG)
- Higure - Blood Alone (Drama CD)
- Hong Lihua/Reika - Super Robot Wars Z (VG)
- Ice Climbers - Super Smash Bros. Ultimate (VG)
- Ice Climbers - Super Smash Brothers Melee (VG)
- Iria Silvestoli - Star Ocean: First Departure (VG)
- Juana Olsys - Atelier Meruru: The Alchmist of Arland 3 (VG)
- Jun Sakurada - Rozen Maiden (Drama CD)
- Kaede Orikura - Otome wa Boku ni Koishiteru (Drama CD)
- Kat - Gravity Daze/Gravity Rush (VG)
- Kat - Playstation All-Stars Battle Royale (VG)
- Leslie Newman - Trauma Center: New Blood (VG)
- Lushean Bronx - Summon Night 4 (VG)
- Lydie Erlanger - Castlevania: Harmony of Dissonance (VG)
- Misaki Ayuzawa - Kaichou wa Maid-sama (Drama CD)
- Misaki - Kaichou wa Maid-sama (Drama CD)
- Misasagi Inori - Memories Off (VG)
- Nancy Callahan - Sin City (Japanese dub)
- Natsumi Raimon - Inazuma Eleven 2 (VG)
- Natsumi Raimon - Inazuma Eleven 3 (VG)
- Natsumi Raimon - Inazuma Eleven Strikers (VG)
- Natsumi Raimon - Inazuma Eleven (VG)
- Ohatsu - Shin Onimusha: Dawn of Dreams (VG)
- Otoha Kijimiya - Hayate x Blade (Drama CD)
- Pai - .hack//G.U. (VG)
- Pi - .hack//Link (VG)
- Rahzel - Hatenkou Yuugi (Drama CD)
- Ridley Timberlake - Radiata Stories (VG)
- Riiko Izawa -Zettai Kareshi (Drama CD)
- Rimu Nanakaze - Inazuma Eleven Strikers (VG)
- Sakura - Goddess of Victory: Nikke (VG)
- Samantha Puckett in iCarly (Japanese dub)
- Seong Mi-na - Soul Calibur IV (VG)
- Seong Mi-na - Soul Calibur: Broken Destiny (VG)
- Snow White/Mary Margaret Blanchard - Once Upon a Time (Japanese dub)
- Tighanri - Genshin Impact (VG)
- Tsukishi Ootani - Inazuma Eleven Strikers (VG)
- Vent and Aile - Rockman ZX (VG)
- White Alien Ranger - Power Rangers in Space (TV series)
- Wilhelm - Breath of Fire 6 (VG)
- Will of the Book of Darkness - Magical Girl Lyrical Nanoha A's Sound Stage 02 (Drama CD)
- Yuki Hirasaka - 7'scarlet (VG)

Marco