Kaede Domyoji is the mother of Tsukasa and Tsubaki. She is a powerful, rich and an extremly cold business woman, owner of her own international hotel line and Domyoji Enterprises. Kaede works and lives mainly in New York, and she never bothered to raise her children. She is not interested in other peoples feelings. Everything should be exactly as she planned.  Once a year she comes home to Japan to celebrate the birthday of her son Tsukasa—the heir of the family fortune.

Makino Tsukushi: a girl who comes from a poor family just wants to get through her 2 last years at Eitoku Gakuen, quietly. But once she makes herself known by standing up for her friend to the F4, the 4 most popular, powerful and rich boys at the school. She gets the red card: F4's way of a "Declaration of War". But when she doesn't let herself be beaten by them and is starting to fall for one of the F4; Hanazawa Rui. She starts to see that there is more than meets the eye...
 
(Source: Anime News Network)

Tsukushi Makino is accepted into the prestigious, Eitoku Academy. Life changes dramatically for Tsukushi when her friend falls on Tsukasa Domyoji. Tsukasa is the explosive leader of the "F4," a group of the most powerful, rich and handsome boys. Domyoji refuses to accept Makiko's apology and Tsukushi steps in to protect her friend. A red tag appears in the Tsukushi's locker the next morning which is a sign from the F4 that she is to be bullied by the school. Tskushi continues to stand up to her oppressors.
 
(Source: Viz Media)
 
Included one-shot: End of the Century