Tsukushi Makino is the main female character, and is one of the very few students at the prestigious Eitoku University to come from an "unwealthy" family. Her family is so poor that they can barely afford to pay Makino's tuition, but her parents push her on to continue school because they have a dream that she can "snag a rich man" and take them out of poverty.  At the beginning of the manga, Makino was a poor, pig-tailed girl who had almost no friends at school and kept to herself. When one of her only friends falls down a staircase and bumps in the leader of the F4, Makino stands up for her friend (Domyoji was about to hurt her for bumping into him) and suffers the consequences.      The next day, a red tag is hanging in her locker, which predicts future torment from the F4 and followers. But, unlike most of the F4's targets, Makino stands up for herself, showing how strong a "weed" can be.     In this process, she changes to let her stubborn, hardworking ways show through, and in the end she turns all of the F4 into her friends.      At first, Makino hates all of the F4 except Hanazawa Rui, (which she has romantic feelings towards). But, as Rui goes off to chase after Shizuka, Makino gets to know them, and even slowly falls in love with the hotheaded leader, Domyoji.

Makino Tsukushi: a girl who comes from a poor family just wants to get through her 2 last years at Eitoku Gakuen, quietly. But once she makes herself known by standing up for her friend to the F4, the 4 most popular, powerful and rich boys at the school. She gets the red card: F4's way of a "Declaration of War". But when she doesn't let herself be beaten by them and is starting to fall for one of the F4; Hanazawa Rui. She starts to see that there is more than meets the eye...
 
(Source: Anime News Network)

Tsukushi Makino is accepted into the prestigious, Eitoku Academy. Life changes dramatically for Tsukushi when her friend falls on Tsukasa Domyoji. Tsukasa is the explosive leader of the "F4," a group of the most powerful, rich and handsome boys. Domyoji refuses to accept Makiko's apology and Tsukushi steps in to protect her friend. A red tag appears in the Tsukushi's locker the next morning which is a sign from the F4 that she is to be bullied by the school. Tskushi continues to stand up to her oppressors.
 
(Source: Viz Media)
 
Included one-shot: End of the Century

Set in an alternative timeline to the TV series and manga, the movie features a classic Cinderella story told through the medium of 80's dance. Tsukushi Makino is a trainee dancer in a New York Performance group, struggling to become the star of the show with the help of Rui Hanazawa and Tsukasa Doumyouji. 
(Source: Anime News Network)

A midquel to Boys Over Flowers, taking place after chapter 177. 
 
It follows Tsukushi Makino and Tsukasa Domyoji, during their early days of dating officially.