Sakurako was the object of torment of the children she went to school with because she was born "ugly". When she confessed her love to Domyouji, he traumatized her by making fun of her looks. She was friend's with Makiko when they were still in Elementary school, but moved to Germany because of her family's business. Sakurako undergoes plastic surgery and returns to Eitoku, determined to use her new beauty to take her revenge on Domyouji by making him fall in love with her. She met Tsukushi when she asked for help at Shizuka's birthday party. She acts sweet and innocent, but lets her true colors show when she thinks no one is watching. When she hears of his growing attraction to Tsukushi, she conspires with her friend Thomas to destroy her. She has Thomas drug Tsukushi at a club and then distributes photos of the two of them in bed together around the school, causing the student body to turn on her for betraying Domyouji. When Tsukushi finds out that Sakurako is behind of this, Sakurako tells Tsukushi that she only used her in order to take revenge on Tsukasa and that she doesn't need any friends and says that ugly and average people like Tsukushi shouldn't be near handsome men like those in the F4. When Domyouji eventually refuses Sakurako's advances and sees through her plans, Sakurako becomes remorseful. She is then bullied by the whole student body because of her plastic surgery, but Tsukushi defends her. Tsukushi then says that she still can't forgive her. Sakurako also takes advantage of the situation to be near with Tsukasa when Tsukasa breaks up with Tsukushi because of her romance with Rui. But Tsukasa only pretends to be close with Sakurako to make Tsukushi jealous. At first, it's unknown whether Sakurako and Tsukushi can still be friends or not, because Sakurako becomes cruel when she is with Tsukasa. But, as the story progresses, Sakurako seems to be more friendly and sometimes defends Tsukushi from other people with malicious intent.  (Source: Wikipedia)

Makino Tsukushi: a girl who comes from a poor family just wants to get through her 2 last years at Eitoku Gakuen, quietly. But once she makes herself known by standing up for her friend to the F4, the 4 most popular, powerful and rich boys at the school. She gets the red card: F4's way of a "Declaration of War". But when she doesn't let herself be beaten by them and is starting to fall for one of the F4; Hanazawa Rui. She starts to see that there is more than meets the eye...
 
(Source: Anime News Network)

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Jocelyne Loewen is a Canadian voice actress working with The Ocean Group, known for her roles in the English-language dubs of anime series, mostly that of "spunky" young girls. In addition to voice work, Jocelyne has also played part in several live-action movies and television shows, including Stargate SG-1, The 4400, The Dead Zone, and Eureka.

Tsukushi Makino is accepted into the prestigious, Eitoku Academy. Life changes dramatically for Tsukushi when her friend falls on Tsukasa Domyoji. Tsukasa is the explosive leader of the "F4," a group of the most powerful, rich and handsome boys. Domyoji refuses to accept Makiko's apology and Tsukushi steps in to protect her friend. A red tag appears in the Tsukushi's locker the next morning which is a sign from the F4 that she is to be bullied by the school. Tskushi continues to stand up to her oppressors.
 
(Source: Viz Media)
 
Included one-shot: End of the Century

Sakurako Sanjo