Speed Grapher follows the exploits of former war photographer Tatsumi Saiga, who investigates a secret fetish club for the ultra-wealthy. He tries to photograph the club's "goddess", a 15-year-old girl named Kagura, but is discovered. As he is about to be killed, Kagura kisses him, granting him the ability to destroy anything he photographs. Kagura's body fluids can give people bizarre abilities related to their fetishes or obsessions. The story develops as Saiga aims to grant Kagura's desire (her freedom), while on the run from the Secret club and the Tennouzu Group mega-corporation that operates it.