The five members of the Cultural Research Club - Taichi Yaegashi, Iori Nagase, Himeko Inaba, Yui Kiriyama, and Yoshifumi Aoki - encounter a bizarre phenomenon one day when Aoki and Yui switch bodies without warning. The same begins to happen to the other club members, throwing their daily lives into disarray. 
At first the five students find some amusement amidst the confusion, but this unwarranted connection also exposes the painful scars hidden within their hearts. As their calm lives are shattered, the relationships between the five students also begin to change... 
(Source: Crunchyroll, edited)

They've already had their bodies swapped like musical chairs, had their ages changed at random and experienced their deepest desires taking control of them without warning, but if you thought Heartseed was finished with Taichi, Iori, Himeko, Yoshifumi and Yui, you've got another thing coming! Now there's a new affliction going around, and the name of this peculiar bug is emotion sickness. As in, suddenly your emotions jump out of your body and sick someone else! Needless to say, that's more than simply awkward if you've got a deep rooted phobia like a fear of men or repressed emotions that you've been trying to keep hidden, but in some situations it can literally be deadly! What is Heartseed up to this time, and why is he making our heroes involuntarily share their innermost dirty laundry? 
 
(Source: Sentai Filmworks)

5 boys and girls full-shuffled! 5-way love pentagon comedy! At clubhouse room 401, there gathers "anything goes" members of the culture study society. Pro-wrestling otaku Taichi Yaegashi, mysterious beauty Iori Nagase, cool Himeko Inaba, the clown Yoshifumi Aoki and fancy-loving Yui Kiriyama found the noisy but calm days suddenly come to a halt. The personality switched among the members--. The unnatural days of changinging into "someone" by getting back to "themselves" by becoming "someone else" has started!

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