Sloth is the fifth Homunculus created by Father. Appearing as a giant, muscular, but mentally slow man, Sloth spends most of the story digging the country spanning underground tunnels that make up the Father's mysterious transmutation circle. A conversation between Greed and Lust implies that Sloth have dug tunnels for at least a hundred years. Not surprisingly, he seems eager to finish his work so he can rest at last.  In the first anime, Sloth was inadvertently created in the failed human transmutation of Ed and Al, and appeared as their mother, quite the opposite of what he is characterized as in Fullmetal Alchemist: Brotherhood.

"In order for something to be obtained, something of equal value must be lost."
 
Alchemy is bound by this Law of Equivalent Exchange—something the young brothers Edward and Alphonse Elric only realize after attempting human transmutation: the one forbidden act of alchemy. They pay a terrible price for their transgression—Edward loses his left leg, Alphonse his physical body. It is only by the desperate sacrifice of Edward's right arm that he is able to affix Alphonse's soul to a suit of armor. Devastated and alone, it is the hope that they would both eventually return to their original bodies that gives Edward the inspiration to obtain metal limbs called "automail" and become a state alchemist, the Fullmetal Alchemist.
 
Three years of searching later, the brothers seek the Philosopher's Stone, a mythical relic that allows an alchemist to overcome the Law of Equivalent Exchange. Even with military allies Colonel Roy Mustang, Lieutenant Riza Hawkeye, and Lieutenant Colonel Maes Hughes on their side, the brothers find themselves caught up in a nationwide conspiracy that leads them not only to the true nature of the elusive Philosopher's Stone, but their country's murky history as well. In between finding a serial killer and racing against time, Edward and Alphonse must ask themselves if what they are doing will make them human again... or take away their humanity.
 
(Source: MAL Rewrite)

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Between voice acting, script-adapting, and directing, Patrick Seitz has had the pleasure of working on hundreds of different video games and anime series over the past 20 years. His voice credits include Endeavor MHA, Franky One Piece, Dio JoJo’s Bizarre Adventure, plus a variety of video game voices like Arthas Menethil and Garrosh Hellscream from World of Warcraft. Seitz’s script-adapting credits include the English dubs of the animated feature films Summer Wars and Wolf Children, as well as series such as Aggretsuko, and he has directed a bevy of Japanese RPGs.

_Source: Crunchyroll Expo 2020_

Alchemy tore the Elric brothers’ bodies apart. Can their bond make them whole again? 
In this world, alchemists are those who study and perform the art of alchemical transmutation—the science of manipulating and transforming matter. They are bounded by the Law of Equivalent Exchange: in order to gain something, one must sacrifice something of equal value. 
In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical “auto-mail” limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother’s bodies...the legendary Philosopher’s Stone.
 
(Source: Viz Media)
 
Note: Includes 8 extra chapters.