Shuuichi is a young trans girl who is one of two main protagonists. She is a fifth grader at the beginning of the series. As she grows up and hits puberty, she becomes increasingly concerned about the way her body is changing.

Shuuichi has an honest and dutiful personality that generally makes it easy for her get along well with others, though she can also be quite sensitive at times. She is often described as cute, and is able to pass as a girl due to her feminine appearance and physical build; she enjoys wearing cute clothes, which her friends encourage. Shuuichi later becomes interested in writing stories, and joins the drama club as a writer. 

Fifth grader Shuuichi Nitori is considered by most to be one of the prettiest girls in school, but much to her dismay, she is actually biologically male. Fortunately, Shuuichi has a childhood friend who shares similar feelings of gender dysphoria: the lanky tomboy Yoshino Takatsuki, who, though biologically female, does not identify as a girl. These two friends share a similar secret and find solace in one another; however, their lives become even more complicated when they must tread the unfamiliar waters of a new school, attempt to make new friends, and struggle to maintain old ones. Faced with nearly insurmountable odds, they must learn to deal with the harsh realities of growing up, gender identity, relationships, and acceptance. 
 
Lauded as a decidedly serious take on gender identity and LGBT struggles, Takako Shimura's Hourou Musuko is about Shuuichi and Yoshino's journey to discover their true selves as they enter puberty, make friends, fall in love, and face real and difficult choices. 
 
Note: The full version of Hourou Musuko was originally intended to be 12 episodes, but the programming block it aired on only had space for 11 episodes. Therefore, episodes 10 and 11 were edited together and aired on TV as episode 10. Episode 12 was aired on TV as episode 11. The full versions of episodes 10 and 11 were included on the BD & DVD releases and are included in the Hourou Musuko Specials entry.

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Fifth grade friends Shuichi Nitori and Yoshino Takatsuki have happy homes, loving families, and are well-liked by their classmates. But they share a secret that further complicates a time of life that is awkward for anyone: Shuichi is a transgender girl, and Yoshino is transgender boy. 
 
(Source: Fantagraphics)

The full versions of episodes 10 and 11 that were previously edited together into episode 10 of the TV series.