In Swallowing the Earth she is an extremely beautiful, mysterious woman first reported on the island of Mamoo in the South Pacific during World War II.  She resurfaces in Japan in the 1960's.  Gohonmatsu Seki is the only man that seems to be immune to her charms. 

She appeared as the Spirit of the West Wind in UNICO and as Konomi Kuwata aka "Black Queen" in Black Jack.

Among adult readers in Japan Black Jack is Osamu Tezuka’s most popular achievement, and perhaps the most close to the creator’s heart, as Tezuka considered entering the medical field—majoring in medicine in college—before devoting his life to comics. Black Jack is a genius surgeon who never acquired his license due to his clashes with the medical establishment. He is hired out by anyone willing to pay his exorbitant rates and is perceived as a heartless rogue because of his enigmatic nature and antisocial manner. But as readers will soon discover, that is not the whole story.
 
(Source: Kodansha USA)
 Note: Won the 1st Kodansha Manga Award in the Shounen category in 1977.

Unico the Unicorn has the amazing power to make anyone he meets happy. Whether it's because of his personality or the powers of his horn, no one knows. However, the gods become jealous of Unico, thinking that only gods should be able to decide or let people be happy or not. Unico is banished to the Hill of Oblivion, and the West Wind is ordered to take him there. She can't stand giving this fate to an innocent like Unico, so Unico's adventures begin, as the West Wind takes him from one place and time to the next, in a neverending journey to escape the wrath of the gods. In this adventure, Unico meets Beezel a devil child and then Katy (Chao), a cat who wants to be a witch! Can he become friends with them? 
(Source: AniDB)

Based on "Unico and the Kingdom of the Sun," which was newly written as a theater version, this animated film features a battle between the wizard Kukuruku and Unico. Kukuruku builds a castle using dolls transformed from men as building parts. The story revolves around the sorrow and terror of men who have been transfigured into dolls, and a girl named Cherry who wishes to recover the kindness in her brother, who is a student of Kukuruku. This work reminds us of the fact that "transformation" or "transfiguration" - favorite themes of Tezuka Osamu - involves not only material aspects, but also man's immaterial heart. 
(Source: Tezuka Osamu's Website)

A little unicorn named Unico lives with his mistress Psyche, bringing her happiness and good fortune in return for her unconditional love. The goddess Venus, however, grows jealous of Psyche's legions of admirers and flings Unico across time and space! When he awakens, he's facing down mean buffalo in the American West, with no memory of Psyche or his past life. It's the first of many exciting adventures that will bring Unico face to face with high society in Imperial Russia, characters from fairy tales and Shakespeare, and even an automated factory intent on blotting out the sun. 
(Source: eManga)

Based on the brilliant maverick doctor created by manga pioneer Osamu Tezuka. This prequel follows Black Jack when he was still a medical student in the 1960s.
 
(Source: Anime News Network)

Amidst the chaos of World War II, two Japanese sailors hear of Zephyrus, an utterly captivating woman in the South Pacific. Many years have since passed, and now Zephyrus has resurfaced in Japan, wielding her mysterious power over all men to exact revenge for their crimes against women since the beginning of time. Gohonmatsu Seki is the only man with the ability to resist her allure, but even he seems ill-equipped to save his gender&hellip; (Source: DMP)